产品货号：
Z28935
中文名称：
UBE2Q2抗体
英文名称：
Anti-UBE2Q2 Antibody
产品规格：
100μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-UBE2Q2 Antibody |
| 指标别名 | UBCi;UBE2Q2;Ubiquitin carrier protein Q2;Ubiquitin protein ligase Q2 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | WB,ELISA |
| 基因名称 | UBE2Q2 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 计算分子量 | 43KD |
| 成分 | Liquid form in PBS containing 50% glycerol,and 0.02% sodium azide. |
| 纯化方式 | UB2Q2 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | -20℃可保存1年，短期保存或频繁使用请置于4℃，可保存一个月，避免反复冻融。 |
| 背景资料 | UBE2Q2 is identified as a putative ubiquitin-conjugating enzyme (E2) in a microarray screen for mitotic regulatory proteins.Its gene is mapped to 15q24.2.UBE2Q2 can covalently bind ubiquitin on the active site cysteine within the UBC domain.Inhibition of UBE2Q2 in HeLa cells causes an early mitotic arrest and increases cytotoxicity when the cells are treated with microtubule-inhibiting agents (MIAs).Changes in cell cycle progression and viability are not observed in the absence of MIA treatment,indicating that UBE2Q2 is involved in the response to MIAs rather than performing a more general function in mitosis.Moreover,inhibition of the UBE2Q2 protein causes cells to undergo a prolonged prophase arrest,suggesting that UBE2Q2 normally functions to antagonize an early mitotic checkpoint.Finally,inhibition of UBE2Q2 also sensitizes cells to the cytotoxic effects of MIAs through caspase-mediated apoptosis that is correlated with PARP1 cleavage. |
| Uniprot ID | Q8WVN8 |
| 基因名全称 | Ubiquitin-conjugating enzyme E2 Q2 |
| 蛋白名全称 | Ubiquitin-conjugating enzyme E2 Q2 |
| 推荐稀释比 | WB 1:500～2000 ELISA 1:5000～20000 |
相关搜索：UBE2Q2抗体，UBE2Q2多抗，Anti-UBE2Q2 Antibody